Screening of JAK-STAT modulators from the antiviral plants of Indian traditional system of medicine with the potential to inhibit 2019 novel coronavirus using network pharmacology

The majority of the bioactives under investigation were predicted to target TNF receptor-associated factor 5 in Janus kinase/signal transducers and activators transcription pathway. Similarly, druglikeness prediction identified vitexilactone possess highest score, i.e., 0.88. Furthermore, proteins targeted pathway also regulate multiple pathways, ErbB, AGE-RAGE, NF-kappa B, Measles, insulin, mTOR, chemokine, Ras, pathways associated with infectious non-infectious pathogenesis, where immune system is compromised. docking study sesaminol 2-O-?-D-gentiobioside binding affinity 3CLpro, PLpro, spike proteins. phylogeny comparison common protein domains other stains microbes like murine hepatitis virus strain A59, avian bronchitis virus, porcine epidemic diarrhea CV777.